Overall, the levels of social isolation have increased since the first waves of the pandemic, in spring, 2020, but have been showing signs of improvement since January 2021. After its initial increase, the percentage of socially isolated respondents declined most among those with high income and education. We also observed a relatively faster drop in isolation among religious and older Americans. Conversely, unemployed and low SES respondents have barely recovered from the increases in social isolation suffered earlier in the pandemic. In addition, different types of support are not equally available across demographics. Men are substantially more isolated than women with respect to emotional support (but about equal in terms of economic); and white respondents are more socially isolated with respect to economic support; but less isolated emotionally relative to other racial/ethnic groups. Finally, we find a strong association between social isolation (specifically, in terms of relationships available for emotional support) and moderate to severe depressive symptoms.